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Recent Publications
pH-Weighted amine chemical exchange saturation transfer echo planar imaging visualizes infiltrating glioblastoma cells
Given the invasive nature of glioblastoma, tumor cells exist beyond the contrast-enhancing (CE) region targeted during treatment. However, areas of non-enhancing (NE) tumors are difficult to visualize and delineate from edematous tissue. Amine chemical exchange saturation transfer echo planar imaging (CEST-EPI) is a pH-sensitive molecular magnetic resonance imaging technique that was evaluated in its ability to identify infiltrating NE tumors and prognosticate survival. Metho
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Aug 132 min read
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Choroid Plexus Cauterization Prevents Postoperative Hydrocephalus in Adult Glioblastoma Resection With Ventricular Entry
Glioblastoma often extends along the subventricular zone and resection frequently results in ventricular entry, which is associated with increased risk of postoperative hydrocephalus. Choroid plexus cauterization (CPC) is a treatment for pediatric hydrocephalus, but its utility in preventing postoperative hydrocephalus following glioblastoma resection with ventricular entry is unknown. We sought to characterize CPC safety and efficacy in preventing postoperative hydrocephalus
Supramaximal Resection in Glioblastoma: Expanding Surgical Boundaries in the Era of Precision Neuro-Oncology-A Systematic Review
Background: Glioblastoma remains the most aggressive and treatment-resistant primary brain tumor, with patient outcomes strongly associated with the extent of surgical resection. Tumor recurrence is largely driven by infiltrating glioma cells that extend beyond the contrast-enhancing margin, which has traditionally served as the boundary for surgical resection. Advances in pre- and intraoperative imaging, functional mapping, and fluorescence guidance have challenged the conve
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